Affiliation:
1. Department of Physical Activity Research National Institutes of Biomedical Innovation, Health and Nutrition Osaka Japan
2. Laboratory of Gut Microbiome for Health, Microbial Research Center for Health and Medicine National Institutes of Biomedical Innovation, Health and Nutrition Osaka Japan
3. Department of Preventive Medicine, Faculty of Medicine Saga University Saga Japan
4. Department of Pharmacy Saga University Hospital Saga Japan
5. Laboratory of Exercise Physiology, Faculty of Sports and Health Science Fukuoka University Fukuoka Japan
Abstract
AbstractPurposeThis study aimed to investigate the association between oxidative balance score (OBS), wherein higher OBSs indicate lower oxidative stress, and high‐sensitivity C‐reactive protein (hs‐CRP), as well as inflammatory scores, in a large cohort of Japanese adults.MethodsIn total, 9703 individuals aged 40–69 years participated in a baseline survey of a population‐based cohort study in Saga, Japan (2005–2007). OBSs were calculated from 11 prooxidant and antioxidant lifestyle factors, including dietary intake, physical activity, alcohol consumption, and smoking status. Lifestyle data, including dietary intake, were obtained using a self‐administered questionnaire. Adjusted geometric means of serum hs‐CRP levels were calculated based on OBS quartiles, and linear trend tests were performed, with adjustments for potential confounders. In addition, an inflammatory cytokine z‐score was constructed and assessed alongside individual markers.ResultsAfter adjusting for multiple confounders in both sexes, the results showed a significant inverse association between OBS and serum hs‐CRP levels in both men and women. These results remained unaltered when the OBS evaluation excluded powerful prooxidants, serum ferritin, or smoking. There was also an association between OBS and lower inflammatory z‐score, indicating reduced overall systemic inflammation.ConclusionsThese findings suggest that a higher OBS, indicating a greater predominance of antioxidants over prooxidant exposure, is associated with lower hs‐CRP levels and reduced systemic inflammation, regardless of sex.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献