Ketoconazole-Associated Liver Injury in Drug-Drug Interaction Studies in Healthy Volunteers

Author:

Banankhah Peymaan S.1,Garnick Kyle A.2,Greenblatt David J.12

Affiliation:

1. Master of Science in Biomedical Sciences Program; Tufts University School of Medicine; Boston Massachusetts USA

2. Graduate Programs in Pharmacology and Drug Development and in Pharmacology and Experimental Therapeutics; Sackler School of Graduate Biomedical Science; Tufts University School of Medicine; Boston Massachusetts USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference65 articles.

1. Effects of the antifungal agents on oxidative drug metabolism: clinical relevance;Venkatakrishnan;Clin Pharmacokinet,2000

2. Liver injury associated with ketoconazole: review of the published evidence;Greenblatt;J Clin Pharmacol,2014

3. The ketoconazole legacy;Greenblatt;Clin Pharmacol Drug Dev,2014

4. FDA Drug Safety Communication: FDA limits usage of Nizoral (ketoconazole) oral tablets due to potentially fatal liver injury and risk of drug interactions and adrenal gland problems 2013

5. European Medicines Agency recommends suspension of marketing authorisations for oral ketoconazole. Benefit of oral ketoconazole does not outweigh risk of liver injury in fungal infections 2013

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