Considering screening for hereditary cancer syndromes at the time of obstetrical prenatal carrier screening

Author:

Perez Luiza1,Dioun Shayan1,Primiano Michelle2,Blank Stephanie V.34,Lipkin Steven5,Ahsan Muhammad Danyal12,Brewer Jesse1ORCID,Fowlkes Rana Khan1,Abdul‐Rahman Omar6,Hou June7,Wright Jason D.7,Kang Hey Joo8,Sharaf Ravi910,Prabhu Malavika11,Frey Melissa K.12ORCID

Affiliation:

1. Department of Obstetrics and Gynecology Division of Gynecologic Oncology Weill Cornell Medicine New York New York USA

2. Genetics and Personalized Cancer Prevention Program Weill Cornell Medicine New York New York USA

3. Department of Obstetrics Gynecology and Reproductive Science Icahn School of Medicine at Mount Sinai Hospital New York New York USA

4. The Blavatnik Family Women's Health Research Institute Icahn School of Medicine at Mount Sinai New York New York USA

5. Department of Medicine and Program in Mendelian Genetics Weill Cornell Medicine New York New York USA

6. Department of Pediatrics Division of Medical Genetics, Weill Cornell Medicine New York New York USA

7. Department of Obstetrics and Gynecology and Herbert Irving Comprehensive Cancer Center Columbia University College of Physicians and Surgeons New York Presbyterian Hospital New York New York USA

8. Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine Weill Cornell Medical Center New York New York USA

9. Division of Gastroenterology Department of Medicine Weill Cornell Medicine New York New York USA

10. Division of Epidemiology Department of Population Health Sciences Weill Cornell Medicine New York New York USA

11. Department of Obstetrics and Gynecology Massachusetts General Hospital Boston Massachusetts USA

Abstract

Preconception and pregnancy represent a unique window of opportunity for women to engage with the health care system. This article explores the possibility of offering testing for cancer‐associated pathogenic variants on obstetrical carrier screening panels.

Publisher

Wiley

Reference57 articles.

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3. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Genetic/Familial High‐Risk Assessment: Colorectal ‐ Version 1.2023 — May 30 2023.2023.

4. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines Version 1.2022): Genetic/Familial High‐Risk Assessment: Breast Ovarian and Pancreatic.2022.

5. Achieving universal genetic assessment for women with ovarian cancer: Are we there yet? A systematic review and meta-analysis

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