Loss of methylation at theIFNGpromoter and CNS-1 is associated with the development of functional IFN-γ memory in human CD4+T lymphocytes

Author:

Dong Jun,Chang Hyun-Dong1,Ivascu Claudia2,Qian Yu3,Rezai Soheila4,Okhrimenko Anna,Cosmi Lorenzo5,Maggi Laura5,Eckhardt Florian6,Wu Peihua7,Sieper Joachim7,Alexander Tobias8,Annunziato Francesco5,Gossen Manfred,Li Jun9,Radbruch Andreas1,Thiel Andreas

Affiliation:

1. Cell Biology Group; German Rheumatism Research Center Berlin; Berlin; Germany

2. Epigenomics AG; Berlin; Germany

3. Regenerative Immunology and Aging; Berlin-Brandenburg Center for Regenerative Therapies; Berlin; Germany

4. Dipartimento di Clinica e Terapia Medica Applicata; Sezione di Reumatologia, Sapienza Università di Roma; Rome; Italy

5. Center of Research, Transfer; High Education DENOTHE, University of Florence; Firenze; Italy

6. B·R·A·H·M·S GmbH; Hennigsdorf; Germany

7. Department of Gastroenterology, Infectiology and Rheumatology; Charité Universitätsmedizin Berlin; Berlin; Germany

8. Department of Rheumatology and Clinical Immunology; Charité Universitätsmedizin Berlin; Berlin; Germany

9. Center for Cardiovascular Research and Institute of Pharmacology; Charité-Universitätsmedizin Berlin; Berlin; Germany

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference51 articles.

1. Immunological memory and protective immunity: understanding their relation;Ahmed;Science,1996

2. CD4 T cells: fates, functions, and faults;Zhu;Blood,2008

3. Two types of murine helper T-cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins;Mosmann;J. Immunol.,1986

4. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming;Seder;Proc. Natl. Acad. Sci. USA,1993

5. A novel transcription factor, T-bet, directs Th1 lineage commitment;Szabo;Cell,2000

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