Rifampin Drug–Drug–Interaction Studies: Reflections on the Nitrosamine Impurities Issue
Author:
Affiliation:
1. Celerion, Scientific Affairs Belfast UK
2. Celerion, Early Clinical Research Belfast UK
3. Celerion, Data Management and Biometrics Montreal Canada
4. Celerion, Scientific Affairs Phoenix Arizona USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2652
Reference33 articles.
1. US Food and Drug Administration.FDA updates and press announcements on nitrosamines in rifampin and rifapentine. Accessed February 7 2022.
2. US Food and Drug Administration.Drug development and drug interactions | table of substrates inhibitors and inducers. Accessed February 7 2022.
3. Effect of P-glycoprotein (P-gp) Inducers on Exposure of P-gp Substrates: Review of Clinical Drug–Drug Interaction Studies
4. The nitrosamine contamination of drugs, part 3: Quantification of 4-Methyl-1-nitrosopiperazine in rifampicin capsules by LC-MS/HRMS
5. Dietary exposure to volatile and non-volatile N-nitrosamines from processed meat products in Denmark
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