Physical function patient‐reported outcomes among adolescent and young adult cancer survivors: A systematic review

Author:

Tanner Sarah1ORCID,Engstrom Teyl1ORCID,Forbes Cheryl1ORCID,Patel Dhaval1ORCID,Lee Wen Ray2ORCID,Walker Rick345ORCID,Bradford Natalie6ORCID,Pole Jason D.17ORCID

Affiliation:

1. Centre for Health Services Research The University of Queensland Herston Queensland Australia

2. Child Health Research Centre The University of Queensland South Brisbane Queensland Australia

3. School of Medicine The University of Queensland Herston Queensland Australia

4. Queensland Children's Hospital Brisbane Queensland Australia

5. Princess Alexandra Hospital Brisbane Queensland Australia

6. Cancer and Palliative Care Outcomes Centre at Centre for Children's Health Research Queensland University of Technology Brisbane Queensland Australia

7. The University of Toronto Dalla Lana School of Public Health Toronto Ontario Canada

Abstract

AbstractBackgroundThe physical challenges faced by adolescents and young adults (AYA) after a cancer diagnosis may be different from those experienced by paediatric and older adult cancer patients. Patient‐reported outcome measures (PROMs) are valuable tools that can be useful in exploring the experiences of AYAs and identifying important issues, recurrent themes and areas to potentially improve quality of life.ObjectiveWe compared patient‐reported physical function outcomes between AYAs diagnosed with cancer and non‐cancer controls.MethodThis paper builds on a scoping review published in early 2023 and focuses on PROMs related to physical function.ResultsThis systematic review includes 16 studies that measured and reported on physical function PROMs in AYA cancer survivors compared with their cancer‐free peers. Of these studies, 14 found that physical function in AYA survivors was significantly worse. This paper also includes a meta‐analysis conducted on 5 studies using the EORTC‐QLQ‐C30 to measure physical function, which found that physical function score was an average of 7.03 (95% CI: −10.21, −3.86) points lower in the AYA cancer group, compared to their cancer free‐peers, a difference that is clinically meaningful.ConclusionsThe results overwhelmingly demonstrate that AYAs post a cancer diagnosis have worse health‐related quality of life from a physical function perspective than their cancer‐free peers, providing a compelling argument for the need to address this issue. All but one of the studies were cross‐sectional, which highlights the need for further assessment of this group longitudinally throughout their cancer journey.

Publisher

Wiley

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