Quantitative determination of paclitaxel and its metabolites, 6α-hydroxypaclitaxel andp-3′-hydroxypaclitaxel, in human plasma using column-switching liquid chromatography/tandem mass spectrometry

Author:

Yamaguchi Hiroaki1,Fujikawa Asuka1,Ito Hajime1,Tanaka Nobuaki1,Furugen Ayako1,Miyamori Kazuaki1,Takahashi Natsuko2,Ogura Jiro1,Kobayashi Masaki1,Yamada Takehiro3,Mano Nariyasu4,Iseki Ken

Affiliation:

1. Faculty of Pharmaceutical Sciences; Hokkaido University; Sapporo; 060-0812; Japan

2. Graduate School of Medicine; Hokkaido University; Sapporo; 060-8638; Japan

3. Department of Pharmacy; Hokkaido University Hospital; Sapporo; 060-8648; Japan

4. Department of Pharmaceutical Sciences; Tohoku University Hospital; Sendai; 980-8574; Japan

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

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