Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native Substrate-Reference-Cited by-同舟云学术

Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native Substrate

Published:2016-10-14 Issue:46 Volume:55 Page:14277-14280
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Sun Huihua¹,Yeo Wan Lin¹,Lim Yee Hwee²,Chew Xinying²,Smith Derek John³⁴,Xue Bo⁵,Chan Kok Ping²,Robinson Robert C.⁵⁶⁷⁸⁹^ORCID,Robins Edward G.¹⁰,Zhao Huimin¹¹¹^ORCID,Ang Ee Lui¹^ORCID

Affiliation:

1. Metabolic Engineering Research Laboratory (MERL); Science and Engineering Institutes; Agency for Science, Technology, and Research (A*STAR); 31 Biopolis Way, Nanos #01-01 Singapore 138669 Singapore

2. Institute of Chemical and Engineering Sciences (ICES); A*STAR; 8 Biomedical Grove, Neuros #07-01/02/03 Singapore 138665 Singapore

3. Bioinformatics Institute; A*STAR; 30 Biopolis Street, Matrix #07-01 Singapore 138671 Singapore

4. Biotransformation Innovation Platform; 61 Biopolis Drive, Proteos #04-14 Singapore 138673 Singapore

5. Institute of Molecular and Cell Biology (IMCB); A*STAR; 61 Biopolis Drive, Proteos #03-15 Singapore 138673 Singapore

6. Department of Biochemistry; Yong Loo Lin School of Medicine; National University of Singapore; Singapore 117597 Singapore

7. NTU Institute of Structural Biology; Nanyang Technological University (NTU); 59 Nanyang Drive Singapore 636921 Singapore

8. School of Biological Sciences; NTU; 60 Nanyang Drive Singapore 637551 Singapore

9. Lee Kong Chian School of Medicine; 50 Nanyang Avenue Singapore 639798 Singapore

10. Singapore Bioimaging Consortium (SBIC); A*STAR; 11 Biopolis way, #02-02 Singapore 138667 Singapore

11. 215 Roger Adams Laboratory, Box C3; University of Illinois at Urbana-Champaign; 600 South Mathews Avenue Urbana IL 61801 USA

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/anie.201606722/fullpdf

Reference54 articles.

1. Fluorine in Pharmaceuticals: Looking Beyond Intuition

2. Fluorine in medicinal chemistry

3. Fluorine in Medicinal Chemistry

4. Applications of Fluorine in Medicinal Chemistry

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