A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile
Author:
Affiliation:
1. Research Centre for Drugs and Diagnostics; Liverpool School of Tropical Medicine; Pembroke Place Liverpool L3 5QA UK
2. Department of Chemistry; University of Liverpool; Liverpool L69 7ZD UK
Funder
Wellcome Trust
Medical Research Council
Mahidol-Liverpool PhD Scholarships
Publisher
Wiley
Subject
General Chemistry,Catalysis
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/anie.201512062/fullpdf
Reference31 articles.
1. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
2. The Molecular Mechanism of Action of Artemisinin—The Debate Continues
3. Facile Oxidation of Leucomethylene Blue and Dihydroflavins by Artemisinins: Relationship with Flavoenzyme Function and Antimalarial Mechanism of Action
4. Further Evidence Supporting the Importance of and the Restrictions on a Carbon-Centered Radical for High Antimalarial Activity of 1,2,4-Trioxanes Like Artemisinin
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