Atom-Specific Mutagenesis Reveals Structural and Catalytic Roles for an Active-Site Adenosine and Hydrated Mg2+ in Pistol Ribozymes-Reference-Cited by-同舟云学术

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Atom-Specific Mutagenesis Reveals Structural and Catalytic Roles for an Active-Site Adenosine and Hydrated Mg2+ in Pistol Ribozymes

Published:2017-11-15 Issue:50 Volume:56 Page:15954-15958
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Neuner Sandro¹,Falschlunger Christoph¹,Fuchs Elisabeth¹,Himmelstoss Maximilian¹,Ren Aiming²,Patel Dinshaw J.³,Micura Ronald¹^ORCID

Affiliation:

1. Institute of Organic Chemistry and Center for Molecular Biosciences (CMBI); Leopold-Franzens University; Innrain 80-82 6020 Innsbruck Austria

2. Life Science Institute; Zhejiang University; Hangzhou 310058 China

3. Structural Biology Program; Memorial Sloan-Kettering Cancer Center; New York NY 10065 USA

Funder

Austrian Science Fund

Österreichische Forschungsförderungsgesellschaft

Publisher

Wiley

Subject

General Chemistry,Catalysis

Reference34 articles.

1. A widespread self-cleaving ribozyme class is revealed by bioinformatics

2. New classes of self-cleaving ribozymes revealed by comparative genomics analysis

3. Crystal structure and mechanistic investigation of the twister ribozyme

4. In-line alignment and Mg2+ coordination at the cleavage site of the env22 twister ribozyme

5. Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme

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3. Chemical Synthesis of Modified RNA;Angewandte Chemie;2024-04-18

4. Atomic Mutagenesis of N⁶-Methyladenosine Reveals Distinct Recognition Modes by Human m⁶A Reader and Eraser Proteins;Journal of the American Chemical Society;2024-03-06

5. Rapid Kinetics of Pistol Ribozyme: Insights into Limits to RNA Catalysis;Biochemistry;2023-06-09

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