The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl‐Acyl Carrier Protein Binding Site of FabI

Author:

Fage Christopher D.1,Lathouwers Thomas2,Vanmeert Michiel3,Gao Ling‐Jie3,Vrancken Kristof4,Lammens Eveline‐Marie2,Weir Angus N. M.5ORCID,Degroote Ruben2,Cuppens Harry6,Kosol Simone1,Simpson Thomas J.5ORCID,Crump Matthew P.5ORCID,Willis Christine L.5ORCID,Herdewijn Piet3,Lescrinier Eveline3,Lavigne Rob2,Anné Jozef4,Masschelein Joleen137ORCID

Affiliation:

1. Department of Chemistry University of Warwick Coventry CV4 7AL UK

2. Laboratory of Gene Technology KU Leuven Kasteelpark Arenberg 21, PO Box 2462 3001 Heverlee Belgium

3. Laboratory for Medicinal Chemistry Rega Institute for Medical Research Herestraat 49, PO Box 1041 3000 Leuven Belgium

4. Laboratory of Molecular Bacteriology Rega Institute for Medical Research Herestraat 49, PO Box 1037 3000 Leuven Belgium

5. School of Chemistry, Cantock's Close University of Bristol Bristol BS8 1TS UK

6. Department of Human Genetics KU Leuven Herestraat 49 3000 Leuven Belgium

7. Laboratory for Biomolecular Discovery and Engineering KU Leuven Kasteelpark Arenberg 31, box 2438 3001 Heverlee Belgium

Funder

Fonds Wetenschappelijk Onderzoek

H2020 Marie Skłodowska-Curie Actions

Publisher

Wiley

Subject

General Chemistry,Catalysis

Reference51 articles.

1.  

2. Staphylococcus aureus: A Well–Armed Pathogen

3. A review of virulence factors, pathogenesis, and antibiotic resistance in Staphylococcus aureus

4.  

5. World Health Organization The Evolving Threat of Antimicrobial Resistance – Options for Action 2012;

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