Fragment Deconstruction of Small, Potent Factor Xa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein-Ligand Complexes-Reference-Cited by-同舟云学术

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Fragment Deconstruction of Small, Potent Factor Xa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein-Ligand Complexes

Published:2011-12-21 Issue:4 Volume:51 Page:905-911
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Nazaré Marc,Matter Hans,Will David W.,Wagner Michael,Urmann Matthias,Czech Jörg,Schreuder Herman,Bauer Armin,Ritter Kurt,Wehner Volkmar

Publisher

Wiley

Subject

General Chemistry,Catalysis

Reference53 articles.

1. Unraveling principles of lead discovery: from unfrustrated energy landscapes to novel molecular anchors.

2. Ligand efficiency: a useful metric for lead selection

3. Ligand efficiency indices for effective drug discovery

4. Fragment-based lead discovery

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