Tandem Acyl Carrier Proteins in the Curacin Biosynthetic Pathway Promote Consecutive Multienzyme Reactions with a Synergistic Effect-Reference-Cited by-同舟云学术

Tandem Acyl Carrier Proteins in the Curacin Biosynthetic Pathway Promote Consecutive Multienzyme Reactions with a Synergistic Effect

Published:2011-03-14 Issue:12 Volume:50 Page:2795-2798
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Gu Liangcai¹²,Eisman Eli B.¹,Dutta Somnath³,Franzmann Titus M.⁴,Walter Stefan⁴,Gerwick William H.⁵,Skiniotis Georgios³,Sherman David H.¹

Affiliation:

1. Life Sciences Institute, Departments of Medicinal Chemistry, Chemistry, and Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109 (USA)

2. Department of Genetics, Harvard Medical School, Boston, MA 02115 (USA)

3. Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 (USA)

4. Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 (USA)

5. Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093 (USA)

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201005280

Reference20 articles.

1. The Chemical Versatility of Natural-Product Assembly Lines

2. Metabolic Coupling of Dehydration and Decarboxylation in the Curacin A Pathway: Functional Identification of a Mechanistically Diverse Enzyme Pair

3. Convergence of isoprene and polyketide biosynthetic machinery: Isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis

4. Metamorphic enzyme assembly in polyketide diversification

5. Structure-Activity Analysis of the Interaction of Curacin A, the Potent Colchicine Site Antimitotic Agent, with Tubulin and Effects of Analogs on the Growth of MCF-7 Breast Cancer Cells

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