Evolved Aliphatic Halogenases Enable Regiocomplementary C−H Functionalization of a Pharmaceutically Relevant Compound-Reference-Cited by-同舟云学术

Evolved Aliphatic Halogenases Enable Regiocomplementary C−H Functionalization of a Pharmaceutically Relevant Compound

Published:2019-11-18 Issue:51 Volume:58 Page:18535-18539
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Hayashi Takahiro¹,Ligibel Mathieu²,Sager Emine²,Voss Moritz¹,Hunziker Jürg²,Schroer Kirsten²,Snajdrova Radka²,Buller Rebecca¹^ORCID

Affiliation:

1. Competence Center for BiocatalysisInstitute of Chemistry and BiotechnologyZürich University of Applied Sciences Einsiedlerstrasse 31 8820 Wädenswil Switzerland

2. Novartis Institutes for BioMedical ResearchGlobal Discovery Chemistry 4056 Basel Switzerland

Funder

Staatssekretariat für Bildung, Forschung und Innovation

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201907245

Reference56 articles.

2. Halogen Atoms in the Modern Medicinal Chemistry: Hints for the Drug Design

3. The unique role of halogen substituents in the design of modern agrochemicals

5. Procedures for the direct replacement of primary hydroxyl groups in carbohydrates by halogen

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