Identification and structural characterization of febuxostat metabolites in rat serum and urine samples using UHPLC–QTOF/MS-Reference-Cited by-同舟云学术

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Identification and structural characterization of febuxostat metabolites in rat serum and urine samples using UHPLC–QTOF/MS

Published:2019-05-26 Issue:9 Volume:33 Page:
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomedical Chromatography

Author:

Zhou Liping¹²,Liu Hexiang³,Xu Zhongyong¹,Guan Su³,Zhang Lei³^ORCID

Affiliation:

1. School of Chemistry and Chemical EngineeringSouth China University of Technology Guangzhou China

2. Evaluation and Monitoring Center of Occupational HealthGuangzhou Twelfth People's Hospital Guangzhou China

3. School of Biology and Biological EngineeringSouth China University of Technology Guangzhou China

Funder

Guangzhou Science, Technology and Innovation Commission

Guangdong Science and Technology Department

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bmc.4568

Reference18 articles.

1. Gout therapeutics: new drugs for an old disease

2. Febuxostat: A selective xanthine-oxidase/xanthine-dehydrogenase inhibitor for the management of hyperuricemia in adults with gout

3. A systematic review and meta-analysis on the safety and efficacy of febuxostat versus allopurinol in chronic gout

4. Data acquisition workflows in liquid chromatography coupled to high resolution mass spectrometry-based metabolomics: Where do we stand?

5. Metabolism and Excretion of [14C] Febuxostat, a Novel Nonpurine Selective Inhibitor of Xanthine Oxidase, in Healthy Male Subjects

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1. Review on in vivo profiling of drug metabolites with LC-MS/MS in the past decade;Bioanalysis;2021-11

2. Pharmacokinetic Characterization of ZT55, A Novel Indole Derivative Isolated from Radix Isatidis, using Liquid Chromatography/Tandem Mass and Q-TOF/Tandem Mass Spectrometry;Current Pharmaceutical Analysis;2021-01-25

3. Anti‐hyperuricemia activity and toxicity prediction of a novel xanthine oxidoreductase inhibitor;Biomedical Chromatography;2019-12-29

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