Adsorbed protein film on pump surfaces leads to particle formation during fill‐finish manufacturing
Author:
Affiliation:
1. Pfizer, Pharmaceutical Research and Development 1 Burtt Rd Andover Massachusetts USA
2. University of North Carolina at Chapel Hill School of Medicine
Publisher
Wiley
Subject
Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27801
Reference43 articles.
1. Monoclonal antibody interactions with micro- and nanoparticles: Adsorption, aggregation, and accelerated stress studies
2. Effects of Surfaces and Leachables on the Stability of Biopharmaceuticals
3. Response of a concentrated monoclonal antibody formulation to high shear
4. A systematic evaluation of mechanisms, material effects, and protein-dependent differences on friction-related protein particle formation in formulation and filling steps
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