Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression

Author:

Ayala Gustavo1,Morello Matteo23,Frolov Anna1,You Sungyong2,Li Rile1,Rosati Fabiana4,Bartolucci Gianluca5,Danza Giovanna4,Adam Rosalyn M3,Thompson Timothy C6,Lisanti Michael P7,Freeman Michael R238,Di Vizio Dolores23

Affiliation:

1. Department of Pathology; Baylor College of Medicine; Houston TX USA

2. Cancer Biology Program; Samuel Oschin Comprehensive Cancer Institute; Cedars-Sinai Medical Center Los Angeles CA USA

3. The Urological Diseases Research Center; Boston Children's Hospital, Harvard Medical School; Boston MA USA

4. Endocrine Unit, Department of Clinical Physiopathology; University of Florence; Florence Italy

5. Department of Pharmaceutical Sciences; University of Florence; Sesto Fiorentino Italy

6. Department of Genitourinary Medical Oncology, Unit 18-3; The University of Texas MD Anderson Cancer Center; Houston TX USA

7. Breast Oncology and Institute of Cancer Sciences, Paterson Institute of Cancer Research; The University of Manchester; Manchester UK

8. Departments of Surgery and Biological Chemistry and Molecular Pharmacology; Harvard Medical School; Boston MA USA

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference70 articles.

1. The reactive stroma microenvironment and prostate cancer progression;Rowley;Endocr Relat Cancer,2012

2. Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model;Tuxhorn;Cancer Res,2002

3. Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling;Tuxhorn;Clin Cancer Res,2002

4. Transforming growth factor-beta promotes invasion in tumorigenic but not in nontumorigenic human prostatic epithelial cells;Ao;Cancer Res,2006

5. Altered TGF-beta signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis;Franco;Cancer Res,2011

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