The −1195G allele increases the transcriptional activity of cyclooxygenase-2 gene (COX-2) in colon cancer cell lines

Author:

Pereira Carina12,Sousa Hugo1,Silva Joana13,Brandão Carla1,Elgueta-Karstegl Claudio4,Farrell Paul J.4,Medeiros Rui15,Dinis-Ribeiro Mário67

Affiliation:

1. Molecular Oncology Group; Investigation Centre, Portuguese Institute of Oncology; Porto Portugal

2. Abel Salazar Institute of Biomedical Sciences; University of Porto; Porto Portugal

3. Research Department; Portuguese League Against Cancer; Porto Portugal

4. Section of Virology; Imperial College Faculty of Medicine; London UK

5. Faculty of Health Sciences of Fernando Pessoa; University of Porto; Porto Portugal

6. Gastroenterology Department; Portuguese Institute of Oncology; Porto Portugal

7. Faculty of Medicine, CINTESIS/Department of Biostatistics and Medical Informatics; University of Porto; Porto Portugal

Funder

Portuguese Society of Gastroenterology

Portuguese Institute of Oncology of Porto

FCT-Fundação para a Ciência e Tecnologia

European Social Funds (ESF) under Human Potential Operation Programme (POPH) from National Strategic Reference Framework

National Strategic Reference Framework

Publisher

Wiley

Subject

Cancer Research,Molecular Biology

Reference20 articles.

1. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas;Eberhart;Gastroenterology,1994

2. The role of prostaglandins and other eicosanoids in the gastrointestinal tract;Wang;Gastroenterology,2005

3. Chapter 2: Mechanistic aspects of COX-2 expression in colorectal neoplasia;Dixon;Recent Results Cancer Res,2013

4. Structure of the human cyclo-oxygenase-2 gene;Appleby;Biochem J,1994

5. Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2;Kosaka;Eur J Biochem,1994

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