Affiliation:
1. Nano Innovation Institute, Inner Mongolia Key Lab of Carbon Nanomaterials, College of Chemistry and Materials Science Inner Mongolia Minzu University Tongliao 028000 China
2. Department of Biomedical Sciences Texas A&M University School of Dentistry Dallas TX 75246 USA
Abstract
AbstractCell‐based nanotherapy holds great potential to transform diagnosis and treatment patterns for human diseases, especially for cardiovascular diseases (CVDs). Surface coating with cell membrane has become a powerful strategy for functionalization of therapeutic nanoparticles to achieve biological performances of superior biocompatibility, immune evasion, and specificity. Additionally, extracellular vesicles (EVs) play key roles in the progression of CVDs with their ability of transferring cargos to distant tissues, thus emerging as an appealing option for the diagnosis and therapy of CVDs. In this review, recent progress in cell‐based nanotherapy for CVDs is summarized, and different sources of EVs and biomimetic nanoplatforms derived from natural cells are highlighted. Meanwhile, their promising biomedical applications in the diagnosis and targeted treatment of different CVDs are also provided, followed by a discussion of their potential challenges and future prospects.
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,Biotechnology