Affiliation:
1. School of Material Engineering Jinling Institute of Technology Nanjing 211169 China
2. Department of Biomedical Engineering College of Engineering and Applied Sciences Nanjing University Nanjing Jiangsu Province 210093 China
3. Tianyuan Honors School Nanjing Medical University Nanjing 211163 China
4. Department of General Surgery Drum Tower Hospital Medical School of Nanjing University 321 Zhongshan Road Nanjing Jiangsu 210008 China
Abstract
AbstractTaxol is one of the most widely used chemotherapeutic agents but is restricted by its poor solubility and severe side effects in clinical practice. To overcome these limitations, pH‐sensitive nanoparticles, Acetalated Dextran6k‐PEG5k‐PLA2k‐Taxol (ADPP‐PTX), non‐pH‐sensitive nanoparticles, and Propionic Anhydride modified Dextran6k‐PEG5k‐PLA2k‐Taxol (PDPP‐PTX) are developed for the delivery of Taxol. Compared with PDPP‐PTX, ADPP‐PTX shows higher sensitivity to acid response and greater anti‐proliferative effect on cancer cells. In the in vivo study, ADPP‐PTX treatment effectively suppresses the growth of tumors, while only half the dose of Taxol is used, which significantly reduces systemic toxicity compared with Taxol and PDPP‐PTX.
Funder
National Laboratory of Solid State Microstructures, Nanjing University
Jinling Institute of Technology