Affiliation:
1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‐Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University Shanghai 201620 China
2. College of Chemistry and Materials Science Jinan University Guangzhou 510632 China
Abstract
AbstractRecently, several immunotherapeutic strategies are extensively studied and entered clinical investigation, suggesting their potential to lead a new generation of cancer therapy. Particularly, a cancer vaccine that combines tumor‐associated antigens and immune adjuvants with a nanocarrier holds huge promise for inducing specific antitumor immune responses. Hyperbranched polymers, such as dendrimers and branched polyethylenimine (PEI) possessing abundant positively charged amine groups and inherent proton sponge effect are ideal carriers of antigens. Much effort is devoted to design dendrimer/branched PEI‐based cancer vaccines. Herein, the recent advances in the design of dendrimer/branched PEI‐based cancer vaccines for immunotherapy are reviewed. The future perspectives with regard to the development of dendrimer/branched PEI‐based cancer vaccines are also briefly discussed.
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,Biotechnology
Cited by
5 articles.
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