Affiliation:
1. School of Materials Science and Engineering Changchun University of Science and Technology Changchun 130022 P. R. China
2. Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China
3. Engineering Research Center of Optoelectronic Functional Materials Ministry of Education Changchun 130022 P. R. China
Abstract
AbstractReactive oxygen species (ROS) in biological tissues are in a state of dynamic balance. However, many diseases such as cancer and inflammation, are accompanied by a long‐term increase in ROS. This situation inspires researchers to use ROS‐sensitive nanocarriers for a site‐specific release of cargo in pathological areas. Polyamino acid materials with good biodegradability, biocompatibility, and regular secondary structure are widely used in the biomedical field. Herein, a new oxidation responsive PEGylated polyamino acid is synthesised for anticancer drug delivery by ring‐opening polymerisation of N‐carboxyanhydrides bearing thioether pendants. The obtained block copolymer mPEG‐b‐PMLG self‐assembles into spherical nanoparticles (NPs) in water with diameter ≈68.3 nm. NMR measurement demonstrated that the hydrophobic thioether pendants in the NPs can be selectively oxidised to hydrophilic sulfoxide groups by H2O2, which will lead to the disassociation of NPs. In vitro drug release results indicated that the encapsulated Nile red is selectively released in the trigger of 10 mM H2O2 in PBS. Finally, anticancer drug doxorubicin (DOX) is encapsulated to the NPs, and the obtained NPs/DOX exhibits an improved antitumor efficacy in 4T1 tumour‐bearing mice and lower cardiotoxicity than free DOX. These results indicates that the mPEG‐b‐PMLG NPs are promising for anticancer drug delivery.
Funder
National Natural Science Foundation of China
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,Biotechnology
Cited by
1 articles.
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