Affiliation:
1. Guangdong Provincial Key Laboratory of Optical Information Materials and Technology, Institute of Electronic Paper Displays South China Academy of Advanced Optoelectronics South China Normal University Guangzhou 510006 P. R. China
2. National Center for International Research on Green Optoelectronics South China Normal University Guangzhou 510006 P. R. China
3. Department of Radiology, The First Affiliated Hospital Sun Yat‐sen University Guangzhou 510080 P. R. China
4. The Fourth Affiliated Hospital of Guangzhou Medical University School of Biomedical Engineering Guangzhou Medical University Guangzhou 511436 P. R. China
Abstract
AbstractAs the core index, how to improve bioavailability of loaded cargoes is a hot topic of drug carriers. In this study, aminated β‐cyclodextrin (β‐CD) as a cross‐linking points is first integrated into 3D poly(acrylamide‐co‐acrylonitrile) (P(AAm‐co‐AN)) network to build up a unique submicrocage (466.2 ± 47.6 nm), featuring upper critical solution temperature (UCST; ≈40 °C), high volume expansion coefficient, and excellent biocompatibility. Hereinto, hydrophobic β‐elemene (ELE) is locally loaded in β‐CD with high loading efficiency (8.72%) and encapsulation efficiency (78.60%) through hydrophobic desolvation and host–guest interaction. Above UCST, the release of the loaded ELE is accelerated to 72.87% in 24 h, together with the enhanced sensitization effect of synergized radiotherapy. Given spontaneous long‐lasting delivery, targeted embolization, and post‐treatment removal of such UCST‐type submicrocage, it is anticipated to provide a novel, facile, efficient, and versatile strategy of comprehensive anticancer treatments for high drug bioavailability.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangdong Province
Higher Education Discipline Innovation Project
Startup Foundation for Introducing Talent of Nanjing University of Information Science and Technology