Hydrophilic, Porous, Fiber‐Reinforced Collagen‐Based Membrane for Corneal Repair

Author:

Li Zhi‐Biao12345,Liu Jia12345,Xu Ying‐Ni12345,Sun Xiao‐Min12345,Peng Yue‐Hai12346,Zhao Qi12345,Lin Yong‐An12345,Huang Yong‐Rui12345,Ren Li12345ORCID

Affiliation:

1. School of Materials Science and Engineering South China University of Technology Guangzhou 510006 P. R. China

2. National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology Guangzhou 510006 P. R. China

3. Key Laboratory of Biomedical Engineering of Guangdong Province South China University of Technology Guangzhou 510006 P. R. China

4. Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of Technology Guangzhou 510006 P. R. China

5. Innovation Center for Tissue Restoration and Reconstruction South China University of Technology Guangzhou 510006 P. R. China

6. Bio‐land Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510005 P. R. China

Abstract

AbstractCollagen membrane with outstanding biocompatibility exhibits immense potential in the field of corneal repair and reconstruction, but the poor mechanical properties limit its clinical application. Polycaprolactone (PCL) is a biodegradable polymer widely explored for application in corneal reconstruction due to its excellent mechanical properties, biocompatibility, easy processability, and flexibility. In this study, a PCL/collagen composite membrane with reinforced mechanical properties is developed. The membrane has a strong composite structure with collagen by utilizing a porous and hydrophilic PCL scaffold, maintaining its integrity even after immersion. The suture retention and mechanical tests demonstrate that compared with the pure collagen membrane, the prepared membrane has a greater tensile strength and twice the modulus of elasticity. Further, the suture retention strength is improved by almost two times. In addition, the membrane remains fully intact on the implant bed in an in vitro corneal defect model. Moreover, the membrane can be tightly sutured to a rabbit corneal defect, progressively achieve epithelialization, and remain unchanged during observation. Overall, the PCL/collagen composite membrane is a promising candidate as a suturable corneal restoration material in clinical keratoplasty.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

National Key Research and Development Program of China

Pearl River S and T Nova Program of Guangzhou Municipality

Publisher

Wiley

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