Affiliation:
1. Pharmaceutical Nanotechnology Department Shiraz University of Medical Sciences Shiraz 71468‐64685 Iran
2. Center for Nanotechnology in Drug Delivery Shiraz University of Medical Sciences Shiraz 71468‐64685 Iran
3. Transplant Research Center Shiraz University of Medical Sciences Shiraz 71937‐11351 Iran
4. Department of Pharmaceutics Shiraz University of Medical Sciences Shiraz 71468‐64685 Iran
Abstract
AbstractSpinal cord injury, traumatic brain injury, and neurosurgery procedures usually lead to neural tissue damage. Self‐assembled peptide (SAP) hydrogels, a type of innovative hierarchical nanofiber‐forming peptide sequences serving as hydrogelators, have emerged as a promising solution for repairing tissue defects and promoting neural tissue regeneration. SAPs possess numerous features, such as adaptable morphologies, biocompatibility, injectability, tunable mechanical stability, and mimicking of the native extracellular matrix. This review explores the capacity of neural cell regeneration and examines the critical aspects of SAPs in neuroregeneration, including their biochemical composition, topology, mechanical behavior, conductivity, and degradability. Additionally, it delves into the latest strategies involving SAPs for central or peripheral neural tissue engineering. Finally, the prospects of SAP hydrogel design and development in the realm of neuroregeneration are discussed.
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2 articles.
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