Affiliation:
1. College of Chemistry and Chemical Engineering Institute of Environmental Science Shanxi University Taiyuan 030006 China
2. School of Chemistry and Chemical Engineering Shanxi Provincial Key Laboratory of Chemical Biosensing Shanxi Datong University Datong 037009 China
Abstract
AbstractImproving the selective delivery and uptake efficiency of chemotherapeutic drugs remains a challenge for cancer‐targeted therapy. In this work, a DNA tetrahedron is constructed as a targeted drug delivery system for efficient delivery of doxorubicin (Dox) into cancer cells. The DNA tetrahedron is composed of a tetrahedral DNA nanostructure (TDN) with two strands of AS1411 aptamer as recognition elements which can target the nucleolin protein on the cell membrane of cancer cells. The prepared DNA tetrahedron has a high drug‐loading capacity and demonstrates pH‐responsive Dox release properties. This enables efficient delivery of Dox into targeted cancer cells while reducing side effects on nontarget cells. The proposed drug delivery system exhibits significant therapeutic efficacy in vitro compared to free Dox. Accordingly, this work provides a good paradigm for developing a targeted drug delivery system for cancer therapy based on DNA tetrahedrons.
Funder
National Natural Science Foundation of China
Shanxi Scholarship Council of China
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,Biotechnology