Decreased plasma acetaminophen glucuronide/acetaminophen concentration ratio warns the onset of acetaminophen‐induced liver injury

Author:

Noda Takumi1,Kato Ryuji1,Ozato Yasuyuki2,Kawai Yuka1,Yamamoto Masato1,Kagawa Yuya1,Azuma Misa1,Yamamoto Kojiro2,Kusanagi Mika2,Uryu Kiyoaki2,Harada Hiromasa2,Ijiri Yoshio1ORCID,Hayashi Tetsuya1,Tanaka Kazuhiko13

Affiliation:

1. Department of Cardiovascular Pharmacotherapy and Toxicology Faculty of Pharmacy Osaka Medical and Pharmaceutical University 4‐20‐1 Nasahara Takatsuki Osaka569‐1094 Japan

2. Yao Tokusyukai General Hospital 1‐17 wakakusacho Yao Osaka581‐0011 Japan

3. Kidney Center Shirasagi Hospital 7‐11‐23 Kumata Higashisumiyoshi‐ku Osaka546‐0002 Japan

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference14 articles.

1. Glutathione Conjugation of 1,2:3,4-Diepoxybutane in Human Liver and Rat and Mouse Liver and Lungin Vitro

2. Acetaminophen-related Hepatotoxicity

3. Candidate Gene Polymorphisms in Patients with Acetaminophen-Induced Acute Liver Failure

4. Transferase as a genetic determinant of acetaminophen toxicity deficiency in bilirubin UDP‐glucuronyl;Morais S. M.;Journal of Pharmacology and Experimental Therapeutics,1988

5. Establishment and characterization of a human hepatocellular carcinoma cell line JHH‐4;Hasumura S.;Human Cell,1988

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