Analytical subcloning of a clonal cell line demonstrates cellular heterogeneity that does not impact process consistency or robustness-Reference-Cited by-同舟云学术

Analytical subcloning of a clonal cell line demonstrates cellular heterogeneity that does not impact process consistency or robustness

Published:2018-05 Issue:3 Volume:34 Page:602-612
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnol Progress

Author:

Scarcelli John J.¹^ORCID,Hone Megan¹,Beal Kathryn¹,Ortega Alejaida¹,Figueroa Bruno²,Starkey Jason A.³,Anderson Karin¹

Affiliation:

1. Cell Line Development; Biotherapeutics Pharmaceutical Sciences, Pfizer Inc; Andover MA 01810

2. Culture Process Development; Biotherapeutics Pharmaceutical Sciences, Pfizer Inc; Andover MA 01810

3. Analytical Research and Development; Biotherapeutics Pharmaceutical Sciences, Pfizer Inc; Chesterfield MO 63017

Publisher

Wiley

Subject

Biotechnology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/btpr.2646/fullpdf

Reference28 articles.

1. Mammalian cell protein expression for biopharmaceutical production;Zhu;Biotechnol Adv.,2012

2. Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells;Mohan;Biotechnol J.,2008

3. Production of recombinant protein therapeutics in cultivated mammalian cells;Wurm;Nat Biotechnol.,2004

4. International Conference on Harmonization of Technical Requirement for Registration of Pharmaceuticals for Human Use, ICH tripartite guidelines for Biological products Q5D 1997

5. Industry view on the relative importance of “clonality” of biopharmaceutical-producing cell lines;Frye;Biologicals.,2016

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool;Vaccines;2024-05-21

2. A nanowell platform to identify, sort and expand high antibody-producing cells;Scientific Reports;2024-04-24

3. A high‐fidelity, dual site‐specific integration system in CHO cells by a Bxb1 recombinase;Biotechnology Journal;2024-02

4. Droplet digital PCR: A comprehensive tool for genetic analysis and prediction of bispecific antibody assembly during cell line development;New Biotechnology;2023-12

5. How to train your cell - Towards controlling phenotypes by harnessing the epigenome of Chinese hamster ovary production cell lines;Biotechnology Advances;2022-05