De novosequencing of highly modified therapeutic oligonucleotides by hydrophobic tag sequencing coupled with LC-MS-Reference-Cited by-同舟云学术

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De novosequencing of highly modified therapeutic oligonucleotides by hydrophobic tag sequencing coupled with LC-MS

Published:2017-01-27 Issue:2 Volume:52 Page:78-93
ISSN:1076-5174
Container-title:Journal of Mass Spectrometry
language:en
Short-container-title:J. Mass Spectrom.

Author:

Goto R.¹,Miyakawa S.²,Inomata E.²,Takami T.³,Yamaura J.²,Nakamura Y.²⁴

Affiliation:

1. Bioanalysis Business Department; CMIC Pharma Science Co., Ltd.; 17-18, Nakahata-cho, Nishiwaki-shi Hyogo 677-0032 Japan

2. Exploratory Research Laboratory; RIBOMIC Inc.; 3-16-13, Shirokanedai, Minato-ku Tokyo 108-0071 Japan

3. Bioanalysis Department; CMIC, Inc.; Hoffman Estates Illinois 60192-3702 USA

4. Institute of Medical Science; The University of Tokyo; 4-6-1 Shirokanedai, Minato-ku Tokyo 108-8639 Japan

Publisher

Wiley

Subject

Spectroscopy

Reference27 articles.

1. Fomivirsen;Perry;Drugs,1999

2. Clinical and preclinical pharmacokinetics and pharmacodynamics of mipomersen (Kynamro): a second-generation antisense oligonucleotide inhibitor of apolipoprotein B;Geary;Clin. Pharmacokinet.,2015

3. Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease;Ng;Nat. Rev. Drug Discov.,2006

4. RNA-based therapeutics: current progress and future prospects;Burnett;Chem. Biol,2012

5. Quality aspects of oligonucleotide drug development: specifications for active pharmaceutical ingredients;Capaldi;Drug Inf. J.,2012

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1. A general LC-MS-based RNA sequencing method for direct analysis of multiple-base modifications in RNA mixtures;Nucleic Acids Research;2019-09-03

2. A general LC/MS-based RNA sequencing method for direct analysis of multiple-base modifications in RNA mixtures;2019-05-20

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