Protected hinge in the immunoglobulin G2-A2 disulfide isoform-Reference-Cited by-同舟云学术

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Protected hinge in the immunoglobulin G2-A2 disulfide isoform

Published:2014-10-23 Issue:12 Volume:23 Page:1753-1764
ISSN:0961-8368
Container-title:Protein Science
language:en
Short-container-title:Protein Science

Author:

Liu Yaoqing Diana¹,Chou Robert Y.-T.¹,Dillon Thomas M.²,Poppe Leszek³,Spahr Chris⁴,Shi Stone D. H.⁴,Flynn Gregory C.¹

Affiliation:

1. Department of Product Attribute Sciences; Amgen Inc; Thousand Oaks California 91320

2. Department of Drug Product Development; Amgen Inc; Thousand Oaks California 91320

3. Department of Molecular Structure and Characterization; Amgen Inc; Thousand Oaks California 91320

4. Department of Biologics Optimization; Amgen Inc; Thousand Oaks California 91320

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/pro.2557/fullpdf

Reference12 articles.

1. Human IGG2 antibodies display disulfide mediated structural isoforms;Wypych;J Biol Chem,2008

2. Structural and functional characterization of disulfide isoforms of the human IGG2 subclass;Dillon;J Biol Chem,2008

3. Determination of Fab-hinge disulfide connectivity in structural isoforms of a recombinant human immunoglobulin G2 antibody;Zhang;Anal Chem,2010

4. Human IgG2 antibody disulfide rearrangement in vivo;Liu;J Biol Chem,2008

5. IgG2 disulfide isoform conversion kinetics;Liu;Mol Immunol,2013

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2. In Situ Quantification of Polysorbate in Pharmaceutical Samples of Therapeutic Proteins by Hydrodynamic Profiling by NMR Spectroscopy;Analytical Chemistry;2019-05-22

3. Rapid, automated characterization of disulfide bond scrambling and IgG2 isoform determination;mAbs;2018-10-02

4. Fluctuations in dissolved oxygen concentration during a CHO cell culture process affects monoclonal antibody productivity and the sulfhydryl‐drug conjugation process;Biotechnology Progress;2018-09-12

5. Direct mass spectrometric characterization of disulfide linkages;mAbs;2018-03-14

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