A liquid chromatography-tandem mass spectrometry method for the quantitative determination of diastereomers of a phosphoramidate nucleotide prodrug (PSI-7851) in human plasma

Author:

Bao Donghui1,Ross Bruce S.1,Sofia Michael J.1

Affiliation:

1. Pharmasset, Inc.; 303A College Road East; Princeton; NJ; 08540; USA

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference25 articles.

1. Separation of individual antiviral nucleotide prodrugs from synthetic mixtures using cross-reactivity of a molecularly imprinted stationary phase;Allender;Analytica Chimica Acta,2001

2. Purification of PMPA amidate prodrugs by SMB chromatography and x-ray crystallography of the diastereomerically pure GS-7340;Chapman;Nucleosides, Nucleotides & Nucleic Acids,2001

3. In vivo pharmacokinetics and metabolism of anti-human immunodeficiency virus agent D4T-5'-[p-bromophenyl methoxyalaninyl phosphate] (SAMPIDINE) in mice;Chen;Drug Metabolism and Disposition: The Biological Fate of Chemicals,2001

4. Department of Health and Human Services, Food and Drug Administration Development of New Stereoisomeric Drugs 1992 http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm122883.htm

5. Recommendations for the bioanalytical method validation of ligand-binding assays to support pharmacokinetic assessments of macromolecules;DeSilva;Pharmaceutical Research,2003

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