Impact of dose distribution by a 3D planning system for brachytherapy with 198Au grains for head and neck cancer

Abstract

AbstractBackgroundThere has been no study in which the correlation between clinical results and dosimetry based on a 3D treatment planning system in patients with 198Au grains for head and neck cancer was evaluated.MethodsThirty‐two patients who were treated with 198Au grains for head and neck cancer were reviewed. Twenty‐five patients were treated with brachytherapy alone and seven patients were treated with a combination of brachytherapy and neoadjuvant external beam radiation therapy.ResultsWith a median observation period of 60 months, the 5‐year local control rate was 82.9%. V85Gy of CTV in patients with local recurrence tended to be lower than that in patients without local recurrence (p = 0.07). The maximum dose of the keratinized gingiva in patients in whom bone exposure occurred was significantly higher than that in patients in whom bone exposure did not occur (p = 0.001).ConclusionsDose distribution with 198Au grains can predict local control and late adverse events.