A multi‐institutional feasibility lead‐in trial of lymphatic mapping with <scp>SPECT</scp>–<scp>CT</scp> for evaluating contralateral disease in lateralized oropharynx cancer using 99m‐technetium sulfur colloid-Reference-Cited by-同舟云学术

A multi‐institutional feasibility lead‐in trial of lymphatic mapping with SPECT–CT for evaluating contralateral disease in lateralized oropharynx cancer using 99m‐technetium sulfur colloid

Published:2024-07-17 Issue: Volume: Page:
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Sarkis Leba Michael¹²^ORCID,Yao Christopher MKL¹²,Hendler Aaron³,Mohan Ravi³,Au Michael⁴,Zhang Han⁴,Eskander Antoine⁵,Higgins Kevin⁵,MacNeil Danielle⁶^ORCID,Tzelnick Sharon¹²,Goldstein David¹²,Hosni Ali⁷,de Almeida John R.¹²^ORCID

Affiliation:

1. Department of Otolaryngology – Head and Neck Surgery Princess Margaret Cancer Centre, University Health Network, University of Toronto Toronto Ontario Canada

2. Department of Surgical Oncology Princess Margaret Cancer Centre, University Health Network, University of Toronto Toronto Ontario Canada

3. Department of Joint Medical Diagnostic Imaging University Health Network Toronto Ontario Canada

4. Department of Otolaryngology – Head and Neck Surgery McMaster University Hamilton Ontario Canada

5. Department of Otolaryngology – Head and Neck Surgery Sunnybrook Health Sciences Centre Toronto Ontario Canada

6. Department of Otolaryngology – Head and Neck Surgery Western University London Ontario Canada

7. Department of Radiation Oncology University Health Network, University of Toronto Toronto Ontario Canada

Abstract

AbstractBackgroundLymphatic mapping with SPECT–CT has been demonstrated to accurately define lymphatic drainage patterns in oropharyngeal cancer but there has yet to be a study demonstrating its feasibility across multiple institutions.MethodsTwelve adult patients with lateralized oropharyngeal carcinoma (T1‐T3) who were planned for definitive or adjuvant radiotherapy without contralateral nodal disease underwent injection of 99‐m technetium sulfur colloid followed by static planar lymphoscintigraphy to verify tracer migration, and SPECT–CT acquired at 30 ± 15 min (optional) and 3 h (±1 h) (mandatory time‐point).ResultsAll 12 patients completed the study with 7/12 patients having the injections performed under local anesthetic and 5 patients requiring general anesthetic. There were no tracer migration failures and there were no serious adverse events or complications encountered. Four out of 12 patients (33%) showed contralateral drainage patterns.ConclusionsLymphatic mapping with SPECT–CT of lateralized oropharyngeal squamous cell carcinoma can be performed safely across multiple institutions.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27871

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