From venoms to BBB shuttles: Synthesis and blood-brain barrier transport assessment of apamin and a nontoxic analog
Author:
Affiliation:
1. Institute for Research in Biomedicine (IRB Barcelona) Barcelona Science Park; Baldiri Reixac 10; Barcelona 08028 Spain
2. Department of Organic Chemistry; University of Barcelona, Martí i Franquès 1-11; Barcelona 08028 Spain
Publisher
Wiley
Subject
Organic Chemistry,Biomaterials,Biochemistry,General Medicine,Biophysics
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/bip.22257/fullpdf
Reference38 articles.
1. Venoms as a platform for human drugs: translating toxins into therapeutics
2. Snake Venom Polypeptides Affecting the Central Nervous System
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4. Shuttle-Mediated Drug Delivery to the Brain
5. Structure-function relations and site of action of apamin, a neurotoxic polypeptide of bee venom with an action on the central nervous system
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