Engineering superactive granulocyte macrophage colony-stimulating factor transferrin fusion proteins as orally-delivered candidate agents for treating neurodegenerative disease

Author:

Heinzelman Pete1,Priebe Molly C.1

Affiliation:

1. Dept. of Chemical, Biological & Materials Engineering; University of Oklahoma; Norman Oklahoma 73019

Funder

National Institutes of Health

Publisher

Wiley

Subject

Biotechnology

Reference22 articles.

1. GM-CSF upregulated in rheumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice;Boyd;J Alzheimers Dis,2010

2. GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice;Kosloski;J Neuroimmunol,2013

3. Immunogenicity of granulocyte-macrophage colony-stimulating factor (GM-CSF) products in patients undergoing combination therapy with GM-CSF;Wadhwa;Clin Cancer Res,1999

4. A role for protein misfolding in immunogenicity of biopharmaceuticals;Maas;J Biol Chem,2007

5. Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery;Bobst;Proc Natl Acad Sci U S A,2012

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