Natural variation in sensory-motor white matter organization influences manifestations of Huntington's disease

Author:

Orth Michael1,Gregory Sarah2,Scahill Rachael I3,Mayer Isabella SM14,Minkova Lora5ORCID,Klöppel Stefan56,Seunarine Kiran K7,Boyd Lara8,Borowsky Beth9,Reilmann Ralf10,Bernhard Landwehrmeyer G.1,Leavitt Blair R11,Roos Raymund AC12,Durr Alexandra13,Rees Geraint2,Rothwell John C4,Langbehn Douglas14,Tabrizi Sarah J15,

Affiliation:

1. Department of Neurology; Ulm University Hospital; Ulm Germany

2. Wellcome Trust Centre for Neuroimaging; University College London; London United Kingdom

3. HD Research Group; UCL Institute of Neurology; Queen Square London United Kingdom

4. Sobell Department of Motor Neuroscience and Movement Disorders; University College London Institute of Neurology; Queen Square London United Kingdom

5. Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging; University Medical Center, Albert-Ludwigs-University Freiburg; Freiburg Germany

6. Department of Neurology, Freiburg Brain Imaging; University Medical Center, Albert-Ludwigs-University Freiburg; Freiburg Germany

7. Developmental Imaging and Biophysics Section; UCL Institute of Child Health; London United Kingdom

8. Centre for Brain Health; University of British Columbia; Vancouver Canada

9. CHDI Foundation Inc; Princeton New Jersey

10. George-Huntington-Institute, Technology-Park Muenster; Muenster Germany

11. Center for Molecular Medicine and Therapeutics and Department of Medical Genetics; Child and Family Research Institute, University of British Columbia; Vancouver Canada

12. Department of Neurology; Leiden University Medical Centre; Leiden Netherlands

13. APHP Department of Genetics; Groupe Hospitalier Pitié-Salpêtrière, and Institut Du Cerveau Et De La Moelle, INSERM U1127, CNRS UMR7225, UPMC Université Paris VI UMR_S1127; Paris France

14. Departments of Psychiatry and Biostatistics; University of Iowa; Iowa City Iowa

15. Department of Neurodegenerative Disease; University College London, Institute of Neurology; Queen Square London United Kingdom

Funder

CHDI Foundation Inc.

the Wellcome Trust

Publisher

Wiley

Subject

Neurology (clinical),Neurology,Radiology, Nuclear Medicine and imaging,Radiological and Ultrasound Technology,Anatomy

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