Eosinophil extracellular traps in respiratory ailment: Pathogenic mechanisms and clinical translation

Abstract

AbstractBackgroundEosinophilic extracellular traps (EETs) are reticular complexes comprising deoxyribonucleic‐Acid (DNA) fibers and granule proteins.AimsEETs play a crucial role in antimicrobial host responses and are pathogenic when overproduced or under degraded. EETs created by eosinophils appear to enable vital immune responses against extra‐cellular pathogens, nevertheless, trap overproduction is evident in pathology.Materials & MethodsAs considerably research is performed, new data affirmed that EETs can alter the outcome of respiratory ailment.ResultsWe probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic, unresolved inflammation.DiscussionWhether EETs can be used as a prospective brand‐new target for the diagnosis, treatment and prognosis of respiratory ailments is a scientific theme worth studying.ConclusionWe probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic, unresolved inflammation.