High Prevalence of Obstructive Sleep‐Disordered Breathing in Pediatric Patients With Turner Syndrome

Author:

Pham Tiffany T.1ORCID,Davis Shanlee M.23ORCID,Tong Suhong4ORCID,Campa Khaled A.1ORCID,Friedman Norman R.156ORCID,Gitomer Sarah A.135ORCID

Affiliation:

1. Department of Otolaryngology–Head and Neck Surgery University of Colorado School of Medicine Aurora Colorado USA

2. Department of Pediatrics, Section of Endocrinology Children's Hospital of Colorado Aurora Colorado USA

3. eXtraOrdinary Kids Turner Syndrome Clinic Children's Hospital of Colorado Aurora Colorado USA

4. Department of Biostatistics and Informatics Colorado School of Public Health Aurora Colorado USA

5. Department of Pediatric Otolaryngology Children's Hospital of Colorado Aurora Colorado USA

6. Children's Sleep Medicine Laboratory Children's Hospital of Colorado Aurora Colorado USA

Abstract

AbstractObjectiveGirls with Turner syndrome (TS) often have features that have been associated with obstructive sleep‐disordered breathing (oSDB). However, little is known about oSDB in TS. Herein, we aimed to characterize oSDB in young patients with TS and identify associated risk factors.Study DesignRetrospective cross‐sectional study.SettingTertiary care pediatric hospital.MethodsWe reviewed medical records for patients diagnosed with TS seen at our institution between October 1, 2007 and December 31, 2019 with the first outpatient visit before age 6 years. The prevalence of oSDB was compared to the general pediatric population with 1‐sample binomial proportion tests. Clinical characteristics were compared between those diagnosed with oSDB and those without oSDB, and risk factors for oSDB were identified.ResultsOf 151 patients with TS, 73 (48%) were diagnosed with oSDB which is 4‐fold higher than the general pediatric population (12%, P < 0.0001). In the multivariable model, adenoid, tonsillar, and inferior turbinate hypertrophy, birthweight, failure to thrive, and older age at the last clinic visit were all associated with increased odds for oSDB.ConclusionYoung children with TS have a high prevalence of oSDB and thus should be screened for oSDB. Polysomnography should be performed in those with associated risk factors and symptoms oSDB. Treatment of oSDB is imperative as individuals with TS are already at increased risk of behavioral problems, neurocognitive deficits, and growth impairment that may be worsened with oSDB.

Publisher

Wiley

Subject

Otorhinolaryngology,Surgery

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