Hydroalkylation of 1,1‐Diarylalkenes Mediated by Magnesium Hydride in Ethereal Solvents-Reference-Cited by-同舟云学术

Hydroalkylation of 1,1‐Diarylalkenes Mediated by Magnesium Hydride in Ethereal Solvents

Published:2024-01-18 Issue: Volume: Page:
ISSN:0018-019X
Container-title:Helvetica Chimica Acta
language:en
Short-container-title:Helvetica Chimica Acta

Author:

Chaisan Nattawadee¹,Yew Kun Tan Eugene¹,Chiba Shunsuke¹^ORCID

Affiliation:

1. School of Chemistry, Chemical Engineering and Biotechnology Nanyang Technological University Singapore 637371 Singapore

Abstract

AbstractA method for the hydroalkylation of 1,1‐diarylalkenes has been developed using magnesium hydride (MgH2) generated in situ by the solvothermal treatment of magnesium iodide (MgI2) with sodium hydride (NaH) in ethereal solvents. The process is initiated by the hydromagnesiation of 1,1‐diarylalkenes with MgH2 to generate 1,1‐diarylethylmagnesium species, which are immediately alkylated with ethereal solvents to construct a diaryl quaternary carbon center in the hydroalkylation products.

Publisher

Wiley

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Drug Discovery,Biochemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hlca.202300212

Reference52 articles.

1. D. Seyferth ‘The Grignard Reagents’ Organometallics2009 28 1598–1605.

2. Z. Rappaport I. Marek ‘The Chemistry of Organomagnesium Compounds’ Wiley-VCH Weinheim Germany 2008.

3. Grignard reagent formation

4. Alkali-Metal-Mediated Synergistic Effects in Polar Main Group Organometallic Chemistry

5. Bimetallic Combinations for Dehalogenative Metalation Involving Organic Compounds

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