Enantio‐ and Diastereoselective (Ipc)<sub>2</sub>BOTf‐Mediated Aldol Reactions of Morpholine Carboxamides-Reference-Cited by-同舟云学术

Enantio‐ and Diastereoselective (Ipc)₂BOTf‐Mediated Aldol Reactions of Morpholine Carboxamides

Published:2023-11-15 Issue:12 Volume:106 Page:
ISSN:0018-019X
Container-title:Helvetica Chimica Acta
language:en
Short-container-title:Helvetica Chimica Acta

Author:

Pedzisa Lee¹,Monastyrskyi Andrii²^ORCID,Parker Camille D.¹,Roush William R.³^ORCID

Affiliation:

1. Department of Chemistry Union College Schenectady, New York 807 Union Street Schenectady NY 12308 USA

2. Department of Drug Discovery Moffitt Cancer Center & Research Institute Tampa FL 33612 USA

3. Department of Chemistry Scripps Research La Jolla CA 92037 USA

Abstract

AbstractHighly enantio‐ and diastereoselective (Ipc)2BOTf mediated aldol reactions of morpholine carboxamides are described. A wide variety of α‐substituted N‐acyl morpholine carboxamides were successfully employed, including α‐bromo, α‐chloro, α‐vinyl and para‐methoxyphenyl morpholine carboxamides which provided the corresponding aldol products in moderate to excellent yields, and generally with high enantio‐ and diastereoselectivities.

Funder

National Institutes of Health

Israel National Road Safety Authority

Publisher

Wiley

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Drug Discovery,Biochemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hlca.202300126

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