Pharmacokinetic Considerations for Combining Antiretroviral Therapy, Direct-Acting Antiviral Agents for Hepatitis C Virus, and Addiction Treatment Medications

Author:

Bednasz Cindy J.1,Venuto Charles S.12,Ma Qing1,Morse Gene D.1

Affiliation:

1. AIDS Clinical Trials Group Pharmacology Specialty Laboratory, New York State Center of Excellence in Bioinformatics and Life Sciences, School of Pharmacy and Pharmaceutical Sciences; University at Buffalo; Buffalo NY USA

2. Center for Human Experimental Therapeutics; University of Rochester; Rochester NY USA

Funder

National Institutes of Health

University of Rochester Center for Human Experimental Therapeutics

National Institute of Allergy and Infectious Diseases

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Reference32 articles.

1. Menon R Badri P Das U Drug-drug interactions with direct-acting antiviral combination therapy of ABT-450/r, ombitasvir, and dasabuvir 54th Interscience Conference on Antimicrobial Agents and Chemotherapy http://www.natap.org/2014/ICAAC/ICAAC_19.htm

2. Intestinal epithelial barrier disruption through altered mucosal microRNA expression in human immunodeficiency virus and simian immunodeficiency virus infections;Gaulke;J Virol,2014

3. Hepatitis C virus-related cirrhosis is a major determinant of the expression levels of hepatic drug transporters;Ogasawara;Drug Metab Pharmacokinet,2010

4. U.S. Food and Drug Administration Drug development and drug interactions: table of substrates, inhibitors and inducers http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm093664.htm.

5. HIV-1 Alters Intestinal Expression of Drug Transporters and Metabolic Enzymes: Implications for Antiretroviral Drug Disposition;Kis;Antimicrob Agents Chemother,2016

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