Affiliation:
1. State Key Laboratory of Food Science and Resources Jiangnan University Wuxi China
2. School of Food Science and Technology Jiangnan University Wuxi China
3. College of Pharmacy Heilongjiang University of Chinese Medicine Harbin China
4. National Engineering Research Center for Functional Food Jiangnan University Wuxi China
Abstract
AbstractBACKGROUNDAcne vulgaris is an inflammatory disease of the pilosebaceous unit of the skin that has serious adverse effects on the physical and mental health of patients. Probiotics are extensively employed in dermatology and could be an alternative option for acne therapy. Here, we evaluated the effect of oral ingestion of live and inactivated Lactobacillus plantarum CCFM8661 on oleic acid‐induced acne using a mouse model.RESULTSResults indicated that live L. plantarum CCFM8661 suppressed skin inflammation and serum hormone (insulin and testosterone) production in acne mice. Parallelly, live L. plantarum CCFM8661 effectively reduced the formation of skin lipids (triglycerides and non‐esterified free fatty acids), and normalized the expression of skin lipid metabolism‐related genes (PPAR‐γ, SREBP‐1c, ACCα, FASN, PPAR‐α, ACOX1, HSL and ATGL). In comparison, inactivated L. plantarum CCFM8661 had no effect on skin inflammation or serum hormone secretion, but decreased skin triglycerides and normalized the expression of skin lipid metabolism‐related genes (PPAR‐γ, SREBP‐1c, FASN and ATGL) in acne mice. Both live and inactivated L. plantarum CCFM8661 raised the richness of gut microbiota, reduced the ratio of Bacteroidetes to Firmicutes and decreased the relative abundance of Staphylococcus in the feces of acne mice.CONCLUSIONOral ingestion of L. plantarum CCFM8661, particularly live cells, could alleviate acne by suppressing skin inflammation, normalizing the metabolism of hormones and skin lipids, which may be achieved by improving the gut microbial ecosystem. © 2023 Society of Chemical Industry.
Funder
Collaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Province
National Natural Science Foundation of China
Subject
Nutrition and Dietetics,Agronomy and Crop Science,Food Science,Biotechnology
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献