Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation

Author:

Lan Huan12,Wu Kun34,Zheng Yong5,Pan Man1,Huang Yi-Chao2,Gao Shuai12,Zheng Qing-Yun2,Zheng Ji-Shen5,Li Yi-Ming67,Xiao Bailong34,Liu Lei12

Affiliation:

1. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry; Tsinghua University; Beijing 100084 China

2. Tsinghua-Peking Center for Life Sciences; Tsinghua University; Beijing 100084 China

3. IDG/McGovern Institute for Brain Research, School of Pharmaceutical Sciences; Tsinghua University; Beijing 100084 China

4. School of Pharmaceutical Sciences; Tsinghua University; Beijing 100084 China

5. High Magnetic Field Laboratory, Chinese Academy of Sciences; Hefei 230031 China

6. School of Medical Engineering; Hefei University of Technology; Hefei 230009 China

7. State Key Laboratory of Medicinal Chemical Biology; Nankai University; Nankai China

Funder

National Science Foundation China

Ministry of Science and Technology of China

Specialized Research Fund for the Doctoral Program of Higher Education

Anhui Provincial Natural Science Foundation

Publisher

Wiley

Subject

Organic Chemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry,Structural Biology

Reference27 articles.

1. Acid-sensing ion channels: a new target for pain and CNS diseases;Sluka;Curr. Opin. Drug. Disc.,2009

2. Acid-sensing ion channels: potential therapeutic targets for neurologic diseases;Liu;Transl. Neurodegener.,2015

3. Acid-sensing ion channels (ASICs): pharmacology and implication in pain;Deval;Pharmacol. Therapeut,2010

4. ASICs as therapeutic targets for migraine;Dussor;Neuropharmacol.,2015

5. Three-finger toxins, a deadly weapon of elapid venom-milestones of discovery;Utkin;Toxicon. Official. J. Int. Soc. Toxinol,2012

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