1. Division of Pharmacokinetics, Toxicology and Targeting; Groningen Research Institute of Pharmacy; University of Groningen; Antonius Deusinglaan 1 9713 AV Groningen The Netherlands
2. Division of Janssen Pharmaceutica NV; Clinical Pharmacology and Pharmacometrics; Janssen Research and Development; Beerse Belgium
3. Department of Pharmacology; Leiden Academic Center for Drug Research; Leiden University; Leiden The Netherlands