Modeling of prolactin response following dopamine D2 receptor antagonists in rats: can it be translated to clinical dosing?

Author:

Taneja Amit1,Vermeulen An2,Huntjens Dymphy R. H.2,Danhof Meindert3,De Lange Elizabeth C. M.3,Proost Johannes H.1ORCID

Affiliation:

1. Division of Pharmacokinetics, Toxicology and Targeting; Groningen Research Institute of Pharmacy; University of Groningen; Antonius Deusinglaan 1 9713 AV Groningen The Netherlands

2. Division of Janssen Pharmaceutica NV; Clinical Pharmacology and Pharmacometrics; Janssen Research and Development; Beerse Belgium

3. Department of Pharmacology; Leiden Academic Center for Drug Research; Leiden University; Leiden The Netherlands

Funder

Dutch Top Institute Pharma

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Reference43 articles.

1. Mechanism-based concepts of size and maturity in pharmacokinetics;Anderson;Annu Rev Pharmacol Toxicol,2008

2. Pharmacokinetic-pharmacodynamic modeling of tolerance to the prolactin-secreting effect of chlorprothixene after different modes of drug administration;Bagli;J Pharmacol Exp Ther,1999

3. Understanding the behavior of systems pharmacology models using mathematical analysis of differential equations: prolactin modeling as a case study;Bakshi;CPT Pharmacometrics Syst Pharmacol,2016

4. What can we learn from rodents about prolactin in humans?;Ben-Jonathan;Endocr Rev,2008

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