Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach-Reference-Cited by-同舟云学术

Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

Published:2020-07-07 Issue:12 Volume:40 Page:1647-1660
ISSN:0260-437X
Container-title:Journal of Applied Toxicology
language:en
Short-container-title:J Appl Toxicol

Author:

Abdullah Rozaini¹²^ORCID,Wesseling Sebastiaan¹,Spenkelink Bert¹,Louisse Jochem¹,Punt Ans¹,Rietjens Ivonne M.C.M.¹

Affiliation:

1. Division of Toxicology Wageningen University Wageningen The Netherlands

2. Department of Environmental & Occupational Health, Faculty of Medicine and Health Sciences Universiti Putra Malaysia Selangor Malaysia

Funder

This research was supported by the Ministry of Education of Malaysia.

Publisher

Wiley

Subject

Toxicology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jat.4024

Reference71 articles.

1. Predicting points of departure for risk assessment based on in vitro cytotoxicity data and physiologically based kinetic (PBK) modeling: The case of kidney toxicity induced by aristolochic acid I

2. Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR

3. Aristolochic acid as a probable human cancer hazard in herbal remedies: a review

4. Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer

5. Role of P450 1A1 and P450 1A2 in Bioactivation versus Detoxication of the Renal Carcinogen Aristolochic Acid I: Studies in Cyp1a1(−/−), Cyp1a2(−/−), and Cyp1a1/1a2(−/−) Mice

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