Affiliation:
1. State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun China
2. School of Applied Chemistry and Engineering University of Science and Technology of China Hefei China
3. Dental Health Department College of Applied Medical Sciences King Saud University Riyadh Saudi Arabia
Abstract
AbstractTumor cells often exhibit metabolic abnormalities to meet the needs of rapid proliferation, and targeting tumor metabolism has become one of the effective strategies for cancer treatment. However, most of the current methods targeting metabolism focus on inhibiting hyperactivated metabolic pathways, hindering their further application. A recent innovative work, proposed a nutrient‐based strategy to reactivate metabolism for tumor therapy by targeting suppressed metabolic pathways. This approach through delivering nutrients to tumor cells directly using nanotechnology indicates that specific nutrients can serve as potent activators of metabolic pathways. As a new direction along the reverse thinking, this study suggests that this nutrient‐based metabolism reactivation strategy will inspire broad applications in the treatment of other diseases associated with metabolic disorders, besides tumor.