Affiliation:
1. Department of Medical Biochemistry and Molecular Biology School of Medicine Jinan University Guangzhou China
2. Departments of Ophthalmology Anatomy Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore
3. The Affiliated Guangdong Second Provincial General Hospital of Jinan University Guangzhou China
4. Department of Laboratory Medicine Guangdong Second Provincial General Hospital Guangzhou China
Abstract
AbstractBody temperature variations, including the generation, transfer, and dissipation of heat, play an important role throughout life and participate in all biological events. Cellular temperature information is an indispensable link in the comprehensive understanding of life science processes, but traditional testing strategies cannot provide sufficient information due to their low precision and inefficient cellular‐entrance. In recent years, with the help of luminescent nanomaterials, a variety of new thermometers have been developed to achieve real‐time temperature measurement at the micro/nano scale. In this review, we summarized the latest advances in several nanoparticles for cellular temperature detection and their related applications in revealing cell metabolism and disease diagnosis. Furthermore, this review proposed a few challenges for the nano‐thermometry, expecting to spark novel thought to push forward its preclinical and translational uses.
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