Extracellular vesicles in skin health, diseases, and aging

Abstract

AbstractThe skin interfaces with the external environment, acting as both a physical barrier and an immunologic defense. The dynamic interactions between various cell types are essential for skin homeostasis and function. Emerging research has unveiled the significant role of extracellular vesicles (EVs) as key mediators of cell communication in regulating many aspects of skin physiological and pathological processes. In this review, we provide an overview of recent advances in understanding the physiological and pathological roles of EVs in skin health, aging, and diseases, and discuss natural and engineered EVs in skin disease treatment along with the potential challenges. The burgeoning area of EVs may expand new therapeutic approaches for various skin disorders and open new avenues for personalized skincare treatments.