The Effect of Theophylline on Estimated Hepatic Blood Flow

Abstract

We observed the effect of aminophylline administration on estimated hepatic blood flow. Indocyanine green (ICG) 0.5 mg/kg was administered as an intravenous bolus dose before and after intravenous infusion of 7 mg/kg aminophylline. Venous blood was collected at timed intervals over 15 minutes to construct ICG concentration‐time graphs. Pharmacokinetic values were calculated using non‐compartmental methods. Estimated hepatic blood flow decreased from 790 ± 190 to 665 ± 100 ml/minute (p < 0.05) after administration of aminophylline.