Genetic Association of Co‐Trimoxazole‐Induced Severe Cutaneous Adverse Reactions Is Phenotype‐Specific: HLA Class I Genotypes and Haplotypes

Author:

Sukasem Chonlaphat123,Pratoomwun Jirawat12,Satapornpong Patompong124,Klaewsongkram Jettanong356,Rerkpattanapipat Ticha37,Rerknimitr Pawinee38,Lertpichitkul Pattamon38,Puangpetch Apichaya12,Nakkam Nontaya9,Konyoung Parinya10,Khunarkornsiri Usanee10,Disphanurat Wareeporn311,Srisuttiyakorn Chutika312,Pattanacheewapull Oranuch13,Kanjanawart Sirimas10,Kongpan Thachanan14,Chumworathayi Pansu15,Saksit Niwat16,Bruminhent Jackrapong17,Tassaneeyakul Wichittra9,Chantratita Wasun18,Pirmohamed Munir19ORCID

Affiliation:

1. Division of Pharmacogenomics and Personalized Medicine Department of Pathology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand

2. Laboratory for Pharmacogenomics Somdech Phra Debaratana Medical Center (SDMC) Ramathibodi Hospital Bangkok Thailand

3. The Thai Severe Cutaneous Adverse Drug Reaction (THAI‐SCAR) Research Group

4. Division of General Pharmacy Practice Department of Pharmaceutical Care Faculty of Pharmacy Rangsit University Pathum Thani Thailand

5. Division of Allergy and Clinical Immunology Department of Medicine Faculty of Medicine Skin and Allergy Research Unit Chulalongkorn University Bangkok Thailand

6. King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand

7. Division of Allergy Immunology and Rheumatology Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand

8. Division of Dermatology Department of Medicine Faculty of Medicine Skin and Allergy Research Unit Chulalongkorn University Bangkok Thailand

9. Department of Pharmacology Faculty of Medicine Khon Kaen University Khon Kaen Thailand

10. Pharmacy Unit Udon Thani Hospital Udon Thani Thailand

11. Division of Dermatology Department of Medicine Faculty of Medicine Thammasat University Pathumthani Thailand

12. Division of Dermatology Department of Medicine Phramongkutklao HospitalPhramongkutklao College of Medicine Bangkok Thailand

13. Pharmacy Department Khon Kaen Hospital Khon Kaen Thailand

14. Department of Pathology Faculty of Medicine Khon Kaen University Thailand

15. Pharmacy Unit Srinagarind Hospital Faculty of Medicine Khon Kaen University Thailand

16. School of Pharmaceutical Sciences University of Phayao Phayao Thailand

17. Division of Infectious Diseases Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand

18. Genomic Medicine Center Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand

19. Department of Molecular and Clinical Pharmacology The Royal Liverpool Broadgreen University Hospitals NHS Trust MRC Centre for Drug Safety Science Liverpool Health PartnersUniversity of Liverpool Liverpool UK

Funder

Chulalongkorn University

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference39 articles.

1. Co-trimoxazole and prevention of relapses of PR3-ANCA positive vasculitis with pulmonary involvement

2. Cotrimoxazole prophylactic treatment prevents malaria in children in sub-Saharan Africa: systematic review and meta-analysis

3. The expanding role of co-trimoxazole in developing countries

4. World Health Organization (WHO).Guidelines on Post‐Exposure Prophylaxis for HIV and the Use of Co‐Trimoxazole Prophylaxis for HIV‐Related Infections Among Adults Adolescents and Children: recommendations for a Public Health Approach.https://www.who.int/hiv/pub/guidelines/arv2013/arvs2013upplement_dec2014/en/(2014).

5. Trimethoprim-sulfamethoxazole-induced Steven Johnson syndrome in an HIV-infected patient

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